Status

CDC Blood Agent

Lethality

High

Agent Type

Chemical blood agent

Delivery

Inhalation, ingestion, absorption

Treatment

Amyl nitrate, sodium nitrate, sodium thiosulfate, and oxygen

Not Contagious

Historic Use


In World War I, the French and British used ineffective 1- and 2-lb cyanide bombs that did not have enough gas to incapacitate. The Japanese also included cyanide in their inventory of chemical and biological weapons during World War II. The insecticide Zyklon B contained hydrogen cyanide and was used by the Germans in the Holocaust. Cyanide was used in the United States to execute prisoners in the gas chamber from 1924 to 1999.

Introduction

Cyanide at its deadliest, is a colorless gas with a bitter almond odor detectable by certain people. It has been developed as the volatile hydrogen cyanide and the more stable cyanogen chloride as chemical weapons. Either formulation is effective as a chemical blood agent that affects cells' ability to utilize oxygen absorbed from the bloodstream.


Delivery

As a solid, cyanide salts can be absorbed through the skin and eyes and can be ingested. Similarly, cyanide liquids and gases can enter the body through contact, ingestion, and most effectively, inhalation. Water can also be contaminated with cyanide.


Production

In the U.S. alone in 2003, the top thirteen manufacturers of hydrogen cyanide produced 2.019 billion pounds to fulfill its demand in other industries such as metallurgy and electroplating. Cyanide can be produced or extracted from many everyday items such as burning cigarettes, plastics, wool, and silk, and from portions of certain plants like the roots of cassava plants and the pits of cherries and apricots.


Mechanism

Cyanide prevents cells from using oxygen, necessary for our cells to live. Cells take in cyanide as it distributes throughout the body. Entering the cells' mitochondria (energy producers), cyanide displaces oxygen bonded to proteins. Those proteins, cytochrome, cannot perform its normal function of producing energy using oxygen. Without that energy production, the cells throughout the body die, resulting in the person's death.


Treatment

The victim should be moved to fresh air and have contaminated clothing removed. Administering amyl nitrite, sodium nitrite, and sodium thiosulfate, antidotes to cyanide, provides cyanide alternate binding sites to cytochrome and produces a toxin less harmful than cyanide. Treatment with oxygen is also advised along with removal of traces of cyanide from the person using soap and water.


Effects

Even a small amount of cyanide can result in rapid breathing, restlessness, dizziness, weakness, headache, nausea, vomiting, and increased heart rate. Prolonged exposure or a larger dose (hydrogen cyanide, 1 part in 500) in an enclosed space could lead to convulsions, low blood pressure, decreased heart rate, loss of consciousness, lung injury, and death in 8-10 minutes due to respiratory failure. Depending on the extent of exposure, survivors may have some heart and brain damage. Also, being toxic itself, the chlorine in cyanogen chloride can cause eye and respiratory tract irritation and potential delayed pulmonary toxicity.


Sources

Scotland Yard, CDC, U.S. Army, eMedicine.com