However, I have to point out that the website video may be hurting game uptake: It’s been frequently observed that many educational games are sub-par compared to games in general, and the short, highly repetitive, thematically-mismatched music in the video will suggest to some that the game suffers the same issues of being overly brief, low on replay value, or even cursed with the same background music. While brevity may not be an issue if a class plan that only allocated a short, in-class period to the game to underscore other material, it does tend to reduce the amount of time students will spend playing the game as homework.

So, my suggestions would be to:

- strip the music track from the website video

- make available a video of the gameplay itself, including the game’s audio

- provide more detail about how long the game might be reasonably played by a student at home, whether a progressive difficulty mode is available, etc.

- make the sourcecode available to encourage enhancement to the game by outsiders, either for lesson/play value or for porting to a free operating system.

Suggestions for extending these games for student learning include:
Fold.It has a protein folding game competition.
How to connect Immune Attack to Fold.It?
Please create a simulation in Immune Attack of RNA transcription and translation into proteins. Then use Interference RNA (RNAi) to stop protein production. Many diseases are related to over production of proteins.
http://fold.it/portal/video_intro
http://fold.it/
http://scratch.mit.edu/projects/GeneMachine/20917
Have kids link to Scratch to import Immune Attack graphics into their Scratch cartoons.
http://scratch.mit.edu/users/GeneMachine
Have kids rewrite DNA for transcription:
http://www.nanoengineer-1.com/content/
http://nanoengineer-1.com/dev1/index.php?option=com_docman&Itemid=67
http://www.nanoengineer-1.com/content/

Secondary infections are a major problem with surgery, AIDS, Cancer. Several new technologies are now becoming available to diagnose and treat these diseases and secondary infections. Immune Attack could simulate a microfluidic chip. Ex. Take nanorobot inside TruArray Chip. Add RNAi and watch outcome.
http://www.anl.gov/Media_Center/News/2008/ES080509.html
http://www.akonni.com/

Get kids to create their own 3D objects to add to Immune Attack:
http://usa.autodesk.com/adsk/servlet/index?siteID=123112&id=7639525
http://www.blender.org/
http://sketchup.google.com

Kids will learn faster if they can interact in 3D.
When they add their graphics they learn.

Kids in hospitals need to be informed about biology and their disease.
A pediatric care facility should educate its patients. Computer games make it easy.
My son was very upset about surgery until he understood the reasons for it.
Immune Attack has helped him to accept treatments he would have resisted.

Thanks for all the support you have given us.

References:
http://www.childlife.org/
http://fas.org/immuneattack/download

Thank you
John Schmidt