FAS - Mousepox Case Study - Module 4.0

Federation of American Scientists Case Studies in Dual Use Biological Research Module 4.0: Mousepox Case Study


(1)	Adapted from National Research Council, Biotechnology Research in an Age of Terrorism, The National Academies Press, Washington, D.C., 2004; available at http://www.nap.edu/books/0309089778/html.

(2)	Bookrags.com, Recombinant DNA; available at http://www.bookrags.com/sciences/genetics/recombinant-dna-gen-04.html.
(3)	FierceBiotech, "Recombinant DNA Technology," Biotech Industry News; available at http://www.fiercebiotech.com/topics/rDNA.asp.
(4)	MacLeod, Ivan, Unregulated Biotechnology Terrorisms New Tool, The Ottawa Citizen, October 27, 2001; available at http://www.organicconsumers.org/corp/biowar103001.cfm.

(5)	Cohen, Jon, Designer Bugs, The Atlantic Monthly, July/August 2002; available at http://www.stevequayle.com/News.alert/03_Disease/030609.designer.bugs.html.


(6)	Mousepox and Bioweapons, Free Republic; Posted September 9, 2002; available at http://www.freerepublic.com/focus/f-news/747502/posts.

(7)	Moran, T. M., Isobe, H., Fernandez-Sesma, A., and Schulman, J. L., Interleukin-4 causes delayed virus clearance in influenza virus-infected mice. J. Virol. 70:5230-5235 (1996) and Bembridge, G. P., Lopez, J. A., Cook, R., Melero, J. A., and Taylor, G., Recombinant vaccinia virus coexpressing the F protein of respiratory syncytial virus (RSV) and interleukin-4 (IL-4) does not inhibit the development of RSV-specific memory cytotoxic T lymphocytes, whereas priming is diminished in the presence of high levels of IL-2 or gamma interferon. J. Virol. 72:4080-4087 (1998). Both of these papers reported on the effects of IL-4 expression on cell-mediated immune response in mice.

(8)	Nowak, Rachel, Killer Virus, New Scientist, January 10, 2001; available at http://www.newscientistspace.com/article/dn311.
(9)	Nowak, Op.Cit.
(10)	British Broadcasting Corporation News, Deadly Virus Fuels Bioterror Fears, January 10, 2001; available at http://news.bbc.co.uk/1/hi/health/1110144.stm.

(11)	Meadows, Michele, "An Update on Smallpox," FDA Consumer Magazine, March-April 2003; available at http://www.fda.gov/fdac/features/2003/203_smallpox.html.